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HRID27059

反应详情

EQUATION

反应方程式

HRID 27059 的结构方程式

REACTANTS

反应物

3
结构：CCO
HCID702

Ethanol

C2H6O

结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：Cl.O=C(O)C1CCN(CCCCOc2ccccc2CCc2ccccc2)CC1
HCID3055344

4-Piperidinecarboxylic acid, 1-(4-(2-(2-phenylethyl)phenoxy)butyl)-, hydrochloride

C24H32ClNO3

PRODUCTS

生成物

1
结构：CCOC(=O)C1CCN(CCCCOc2ccccc2CCc2ccccc2)CC1.Cl
HCID20545008

未命名化合物

收率 87%

PROCEDURE

实验过程

To a solution of 3 g of 2-[4-(4-carboxypiperidino)butoxy]bibenzyl hydrochloride in 30 ml of ethanol was added dropwise 0.9 g of thionyl chloride. The reaction mixture was stirred for one hour, heated under reflux for 30 minutes, concentrated in vacuo and then recrystallized from ethanolether to give 2.8 g (87% yield) of 2-[4-(4-ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride, m. p. 84°-87° C.

WORKUP

后处理

  1. temperatureheated
  2. temperatureunder reflux for 30 minutes
  3. concentrationconcentrated in vacuo
  4. customrecrystallized from ethanolether