HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-[4-(4-Ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Piperidinecarboxylic acid, 1-(4-(2-(2-phenylethyl)phenoxy)butyl)-, hydrochloride | HCID 3055344 | — |
| Product | 2-[4-(4-Ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride | HCID 20545008 | 87% |
Reaction Steps
To a solution of 3 g of 2-[4-(4-carboxypiperidino)butoxy]bibenzyl hydrochloride in 30 ml of ethanol was added dropwise 0.9 g of thionyl chloride. The reaction mixture was stirred for one hour, heated under reflux for 30 minutes, concentrated in vacuo and then recrystallized from ethanolether to give 2.8 g (87% yield) of 2-[4-(4-ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride, m. p. 84°-87° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04220603 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-5f07fd8899e14afd9f3ec1f1a935fa8f |
| Source note | uspto-grants-1980_09 |