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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 270596Generated: November 2, 2026

Hydrochloric Acid → HCID 68597258, compound

https://huagongshe.com/reaction/270596

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86633370HCID 86633370—
SolventDiethyl EtherHCID 3283—
SolventTetrahydrofuranHCID 8028—
ProductHCID 68597258HCID 6859725898.7%

Reaction Steps

tert-Butyl [(3R)-3-(1-hydroxy-1-methylethyl)-3-(4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-ylcarbonyl)cyclopentyl]carbamate (75 mg, 0.15 mmol) was mixed with a 2.00 M solution of hydrogen chloride in ether (2 mL) and tetrahydrofuran (1 mL). After being stirred for 1 h at room temperature, the reaction solution was concentrated to provide the desired product (70 mg, 98.7%). LCMS calculated for C17H28F3N4O2: (M+H) 473.2; found 473.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07449467B2
Source datasetuspto-grants-2008_11
ORD IDord-edc0c20438b341b188c4a0a9e8452459
Source noteuspto-grants-2008_11