Hydrochloric Acid → HCID 68597258, compound

HRID 270596Notes

Reaction equation

HRID 270596 reaction equation
[OH:1][C:2]([C@@:5]1([C:18]([N:20]2[CH2:25][CH2:24][N:23]([C:26]3[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][N:27]=3)[CH2:22][CH2:21]2)=[O:19])[CH2:9][CH2:8][CH:7]([NH:10]C(=O)OC(C)(C)C)[CH2:6]1)([CH3:4])[CH3:3].[ClH:36]>CCOCC.O1CCCC1>[ClH:36].[ClH:36].[NH2:10][C@H:7]1[CH2:8][CH2:9][C@@:5]([C:2]([OH:1])([CH3:3])[CH3:4])([C:18]([N:20]2[CH2:21][CH2:22][N:23]([C:26]3[CH:31]=[C:30]([C:32]([F:34])([F:35])[F:33])[CH:29]=[CH:28][N:27]=3)[CH2:24][CH2:25]2)=[O:19])[CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86633370HCID 86633370, compound

Product 1

HCID 68597258HCID 68597258, compoundYield 98.7%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

tert-Butyl [(3R)-3-(1-hydroxy-1-methylethyl)-3-(4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-ylcarbonyl)cyclopentyl]carbamate (75 mg, 0.15 mmol) was mixed with a 2.00 M solution of hydrogen chloride in ether (2 mL) and tetrahydrofuran (1 mL). After being stirred for 1 h at room temperature, the reaction solution was concentrated to provide the desired product (70 mg, 98.7%). LCMS calculated for C17H28F3N4O2: (M+H) 473.2; found 473.2.

Workup

  1. concentrationthe reaction solution was concentrated

Sources & evidence

ORD record
ord-edc0c20438b341b188c4a0a9e8452459
Source dataset
uspto-grants-2008_11
Patent number
US07449467B2

Reaction notes

Loading…