HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 4H-[1,3]dioxino[5,4-c]isoquinolin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Reactant | 2,2-Dimethylpropane-1-sulfonamide | HCID 18348400 | — |
| Reactant | HCID 178502595 | HCID 178502595 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4H-[1,3]dioxino[5,4-c]isoquinolin | HCID 70329483 | — |
Reaction Steps
Reaction Conditions: (1) MeOK in DMPU; (2) MCPBA in CH2Cl2; (3) POCl3 in DCE; (4) BBr3 in CH2Cl2; (5) HCHO solution in 40% H2SO4 by procedure of Synthesis of 1,3-oxazino[5,6-c]isoquinolines and related compounds. Miyoko Toyama and Hirotaka Otomasu, Chem. Pharm. Bull. 33(12), 5543-5546, 1985; (6) Fluororination procedure by Uchibori, Y.; Umeno, M.; Yoshiokai, H.; Heterocycles, 1992, 34 (8), 1507-1510
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449479B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-ee028ef7ed814ea380d35123c1894191 |
| Source note | uspto-grants-2008_11 |