反应详情

Cinacalcet base is dissolved in absolute Ethanol (4 volumes per gram of Cinacalcet base). Then 1N HCl (1.5 eq) is added drop-wise. The obtained mixture is stirred at room temperature for 20 hours to obtain a precipitate. The product is isolated by filtration, washed with water, and dried in a vacuum oven at 50° C. for 24 hours to obtain Cinacalcet hydrochloride.

1. customto obtain a precipitate
2. customThe product is isolated by filtration
3. washwashed with water
4. customdried in a vacuum oven at 50° C. for 24 hours