Hydrochloric Acid → Cinacalcet Hydrochloride

HRID 270746Notes

Reaction equation

HRID 270746 reaction equation
[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]>C(O)C>[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 156419Cinacalcet

Product 1

HCID 156418Cinacalcet Hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Cinacalcet base is dissolved in absolute Ethanol (4 volumes per gram of Cinacalcet base). Then 1N HCl (1.5 eq) is added drop-wise. The obtained mixture is stirred at room temperature for 20 hours to obtain a precipitate. The product is isolated by filtration, washed with water, and dried in a vacuum oven at 50° C. for 24 hours to obtain Cinacalcet hydrochloride.

Workup

  1. customto obtain a precipitate
  2. customThe product is isolated by filtration
  3. washwashed with water
  4. customdried in a vacuum oven at 50° C. for 24 hours

Sources & evidence

ORD record
ord-2780e7ed65d04350bec059c7e44dd66f
Source dataset
uspto-grants-2008_11
Patent number
US07449603B2

Reaction notes

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