HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Cinacalcet Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Cinacalcet | HCID 156419 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | Cinacalcet Hydrochloride | HCID 156418 | — |
Reaction Steps
Cinacalcet base is dissolved in MTBE (20 volumes per gram of Cinacalcet base). Then HCl gas (2 eq) is bubbled into the solution at room temperature. The obtained slurry is stirred for 2 hours at room temperature. The product is isolated by filtration, washed with MTBE, and dried in a vacuum oven at 50° C. for 24 hours to obtain Cinacalcet hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449603B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-3a41194940d347fb9521466f337ec1fe |
| Source note | uspto-grants-2008_11 |