反应详情

Cinacalcet base is dissolved in MTBE (20 volumes per gram of Cinacalcet base). Then HCl gas (2 eq) is bubbled into the solution at room temperature. The obtained slurry is stirred for 2 hours at room temperature. The product is isolated by filtration, washed with MTBE, and dried in a vacuum oven at 50° C. for 24 hours to obtain Cinacalcet hydrochloride.

1. customThe product is isolated by filtration
2. washwashed with MTBE
3. customdried in a vacuum oven at 50° C. for 24 hours