反应详情

温度

20 °C

Triethylamine (3.03 g.) is added to a suspension of 2-(5-chloropyrid-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (3.8 g.) and 1-ethoxycarbonylpiperazine hydrochloride (4.86 g.) in acetonitrile (50 cc.), and the mixture is stirred for 18 hours at a temperature of about 20° C. Water (100 cc.) is then added and the insoluble product is filtered off and washed with water (10 cc.). After drying, a product (4 g.) is obtained which, after recrystallisation from acetonitrile (30 cc.), gives 2-(5-chloropyrid-2-yl)-3-(4-ethoxycarbonylpiperazin-1-yl)carbonyloxy-isoindolin-1-one (2.8 g.) melting at 160° C.

1. filtrationthe insoluble product is filtered off
2. washwashed with water (10 cc.)
3. customAfter drying
4. customa product (4 g.) is obtained which
5. customafter recrystallisation from acetonitrile (30 cc.)