反应详情

AIBN (10 mg) was added to a solution of (3-Methoxy-phenyl)-acetic acid methyl ester (2 g, 11 mmol) in CCl4 (30 ml). The solution was then heated to reflux and NBS (2.3 g, 13 mmol) was added in portions. After complete addition the reaction mixture was refluxed for 4 h. After cooling, solid residue was filtered off and the filtrate concentrated to yield product Bromo-(3-methoxy-phenyl)-acetic acid methyl ester, that was washed repeatedly with pet ether.

1. temperatureThe solution was then heated
2. temperatureto reflux
3. additionAfter complete addition the reaction mixture
4. temperaturewas refluxed for 4 h
5. temperatureAfter cooling
6. filtrationsolid residue was filtered off
7. concentrationthe filtrate concentrated