Triethylamine hydrochloride → HCID 178515321, compound

HRID 270969Notes

Reaction equation

HRID 270969 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[NH:16][C:17]3[N:18]([N:28]=[C:29]([C:31]4[NH:35][N:34]=[N:33][N:32]=4)[CH:30]=3)[C:19](=[O:27])[C:20]=2[CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=NN=N1.[N-]=[N+]=[N-].[Na+].Cl.C(N(CC)CC)C>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[NH:16][C:17]3[N:18]([N:28]=[C:29]([C:31]4[NH:32][N:33]=[N:34][N:35]=4)[CH:30]=3)[C:19](=[O:27])[C:20]=2[CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 178515322HCID 178515322, compound

Product 1

HCID 178515321HCID 178515321, compound

Procedure

This material was then converted to the corresponding tetrazole 5-(4-benzyloxy-phenyl)-6-cyclohexyl-2-(1H-tetrazol-5-yl)-4H-pyrazolo[1,5-a]pyrimidin-7-one (551) via a previously described (sodium azide, triethylamine hydrochloride) experimental procedure (54% yield); LC-MS—calcd for C26H25N7O2 [M++H]+: 468.21, found: 468.2.

Sources & evidence

ORD record
ord-3b12b2888d0f432aa2684ecff8f912b9
Source dataset
uspto-grants-2008_11
Patent number
US07449488B2

Reaction notes

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