1-Methylimidazole → HCID 178480889, compound

HRID 271028Notes

Reaction equation

HRID 271028 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[C:30]2[CH:29]=[CH:28][C:16]3[C:17](=[O:27])[N:18]([CH2:24][CH2:25][Br:26])[C:19](=[O:23])[C:20]4=[CH:21][CH:22]=[C:13]([C:14]=2[C:15]=34)[C:12]1=[O:31])([CH3:4])([CH3:3])[CH3:2].[CH3:32][N:33]1[CH:37]=[CH:36][N:35]=[CH:34]1>C(#N)C>[Br-:26].[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[C:30]2[CH:29]=[CH:28][C:16]3[C:17](=[O:27])[N:18]([CH2:24][CH2:25][N+:35]4[CH:36]=[CH:37][N:33]([CH3:32])[CH:34]=4)[C:19](=[O:23])[C:20]4=[CH:21][CH:22]=[C:13]([C:14]=2[C:15]=34)[C:12]1=[O:31])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 13901-MethylimidazoleHCID 86613513HCID 86613513, compound

Product 1

HCID 178480889HCID 178480889, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.40 g (0.84 mmol) of 1-(2-tert. butylphenyl)-6-(2-bromoethyl)-1H-indolo[5,4,3-def]isoquinoline-2,5,7(6H)-trione from Step 1 was dissolved in 40 mL of acetonitrile. After adding 0.35 g (4.20 mmol) of N-methylimidazole, the mixture was stirred at reflux for 2 hours. After removing the solvent, the precipitate was filtered off, washed with ethyl acetate and dried.

Workup

  1. temperatureat reflux for 2 hours
  2. customAfter removing the solvent
  3. filtrationthe precipitate was filtered off
  4. washwashed with ethyl acetate
  5. customdried

Sources & evidence

ORD record
ord-5d571e4940154d7bbc239c0e1997e930
Source dataset
uspto-grants-2008_11
Patent number
US07452385B2

Reaction notes

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