Succinic Acid → HCID 131727182, compound

HRID 271034Notes

Reaction equation

HRID 271034 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][CH:5]([O:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:18]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1.[ClH:23].[C:24]([OH:31])(=[O:30])[CH2:25][CH2:26][C:27]([OH:29])=[O:28]>C(#N)C>[CH3:1][NH:2][CH2:3][CH2:4][CH:5]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:22])[F:21])=[CH:15][CH:14]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1.[ClH:23].[C:24]([OH:31])(=[O:30])[CH2:25][CH2:26][C:27]([OH:29])=[O:28]

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 62857Fluoxetine hydrochloride

Product 1

HCID 131727182HCID 131727182, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In another preparation, a 5.00 g sample of fluoxetine HCl and 0.85 g of succinic acid were dissolved in acetonitrile with heating. The solution was allowed to crystallize in an open evaporating dish over a 15 minute period. The solid material was isolated on filter paper and dried to yield 5.40 g (92% yield) of fluoxetine HCl:succinic acid (2:1) cocrystal.

Workup

  1. customIn another preparation
  2. temperaturewith heating
  3. customto crystallize in an open evaporating dish over a 15 minute period
  4. customThe solid material was isolated
  5. filtrationon filter paper
  6. customdried

Sources & evidence

ORD record
ord-b66b8e232b4f4b0c81684e840b6dbdbe
Source dataset
uspto-grants-2008_11
Patent number
US07452555B2

Reaction notes

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