Hydrochloric Acid → HCID 10226339, compound

HRID 271052Notes

Reaction equation

HRID 271052 reaction equation
[CH2:1]([N:3]([CH2:29][CH3:30])[CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH:15][S:16]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:13]=2)[NH:8][CH:7]=1)[CH3:2].[ClH:31]>C(O)C>[ClH:31].[CH2:29]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH:15][S:16]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][CH:20]=3)(=[O:17])=[O:18])[CH:13]=2)[NH:8][CH:7]=1)[CH3:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10180527N-[3-[2-(diethylamino)ethyl]-1H-indol-5-yl]naphthalene-1-sulfonamide

Product 1

HCID 10226339HCID 10226339, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

1.05 g (2.5 mMol)-of N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-1-sulphonamide (example 2) are dissolved in 10 ml of ethanol and 0.6 ml are added of a 4.2 N solution of hydrochloric acid in ethanol. It is allowed to crystallise at ambient temperature. N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-1-sulphonamide hydrochloride is obtained as a solid with m.p.=255-257° C.

Workup

  1. customto crystallise at ambient temperature

Sources & evidence

ORD record
ord-b951dc2c51e54411a0999f86b3861bf6
Source dataset
uspto-grants-2008_11
Patent number
US07452881B2

Reaction notes

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