反应详情

4-Fluoroaniline (0.7 ml, 7.6 mmol) was added to 2-methylenebutanedioic acid (1.0 g, 7.6 mmol) in a sealed tube. The mixture was heated to 110 degrees for 3 hours after which a precipitate formed. The reaction was filtered and the solid was dissolved in ethyl acetate and concetrated to yield 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (M+1=223.8). The product was taken to next step without determining mass.

1. temperatureThe mixture was heated to 110 degrees for 3 hours after which a precipitate
2. customformed
3. filtrationThe reaction was filtered
4. dissolutionthe solid was dissolved in ethyl acetate