反应详情

A solution of N-(3,4-dimethoxybenzyl)-6-(2-furyl)-1H-purine-2-amine (194 mg, 0.55 mmol) in TFA (1 mL) was heated at 60° C. for 30 min, poured into water, extracted with EtOAc and the combined organic phase was dried (MgSO4), concentrated in vacuo and purified by chromatography (SiO2; 5% MeOH in EtOAc). The resulting yellow solid was dissolved in MeOH, treated with HCl (1-M in Et2O) and filtered to give the title compound (75 mg, 57%) as a yellow solid.

1. extractionextracted with EtOAc
2. dry with materialthe combined organic phase was dried (MgSO4)
3. concentrationconcentrated in vacuo
4. custompurified by chromatography (SiO2; 5% MeOH in EtOAc)
5. dissolutionThe resulting yellow solid was dissolved in MeOH
6. additiontreated with HCl (1-M in Et2O)
7. filtrationfiltered