Sodium Hydroxide → HCID 59834998, compound

HRID 271262Notes

Reaction equation

HRID 271262 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]([O:14]CC)=[O:13])=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[N:3]=1.[OH-].[Na+].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>CO.O>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]([OH:14])=[O:13])=[C:4]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)[N:3]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 2724141Tetrabutylammonium FluorideHCID 59835002HCID 59835002, compound

Product 1

HCID 59834998HCID 59834998, compoundYield 72.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of ethyl 2-amino-6-(2-furyl)-9H-purine-9-acetate (200 mg, 0.69 mmol) in MeOH (3 mL) was treated with aq NaOH (2-M, 0.5 mL, 1 mmol), refluxed for 10 min, cooled, diluted with water, acidified with aq HCl (1-M) and the resulting solid filtered, washed with water and dried to give the title compound (129 mg, 72%) as a yellow solid.

Workup

  1. temperaturerefluxed for 10 min
  2. temperaturecooled
  3. filtrationthe resulting solid filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-dd13ad71030e4083a0cbcf23820a6b8d
Source dataset
uspto-grants-2008_11
Patent number
US07452894B2

Reaction notes

Loading…