Dichloromethane → HCID 67424710, compound

HRID 271282Notes

Reaction equation

HRID 271282 reaction equation
[NH2:1][NH2:2].[CH3:3][C:4]1[CH:5]=[C:6]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([CH:28]=O)[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(Cl)Cl>CC(O)C>[N:1](=[CH:28][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][N:19]=[C:18]2[NH:17][C:6]1[CH:7]=[CH:8][C:9]([O:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:4]([CH3:3])[CH:5]=1)[NH2:2]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 9321HydrazineHCID 86031658HCID 86031658, compound

Product 1

HCID 67424710HCID 67424710, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

(6-Hydrazonomethylquinazolin-4-yl)-(3-methyl-4-phenoxyphenyl)amine is prepared by adding hydrazine (50 mg, 1.00 mmol) to a solution of 4-(3-methyl-4-phenoxyphenylamino)-quinazoline-6-carbaldehyde (250 mg, 0.70 mmol) in a 1:1 mixture of DCM:IPA (6 mL). After stirring at room temperature for 4 hours, excess hydrazine and solvent are removed under reduced pressure to give the desired hydrazone as a brown solid which is carried forward without purification.

Workup

  1. customexcess hydrazine and solvent are removed under reduced pressure

Sources & evidence

ORD record
ord-9f30698684cd4de39e8a7a8e5e50bd4b
Source dataset
uspto-grants-2008_11
Patent number
US07452895B2

Reaction notes

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