反应详情

(4-Amino-tetrahydropyran-4-yl)-methanol is prepared by adding LAH (99%, 1.2 g), portionwise, to a stirred mixture of 4-aminotetrahydropyran-4-carboxylic acid hydrochloride (2.0 g, 11.0 mmol) in THF (30 mL) at 0° C. Upon completion of addition, the reaction mixture is warmed to room temperature and stirred for 1 hour. The reaction mixture is cooled to 0° C. and cautiously quenched by the portionwise addition of Na2SO4.10H2O (4 g). The reaction mixture is diluted with ethyl acetate, warmed to room temperature, and filtered through Celite to give the desired product.

1. custom(4-Amino-tetrahydropyran-4-yl)-methanol is prepared
2. additionUpon completion of addition
3. temperatureThe reaction mixture is cooled to 0° C.
4. customcautiously quenched by the portionwise addition of Na2SO4.10H2O (4 g)
5. additionThe reaction mixture is diluted with ethyl acetate
6. temperaturewarmed to room temperature
7. filtrationfiltered through Celite