反应详情

温度

-78 °C

The mixture of 500 mg of 3-bromochlorobenzen and 3 ml of tetrahydrofuran was cooled down to −78° C. and 1.3 ml of 2.0M lithium diisopropylamide heptane/tetrahydrofuran/ethylbenzene solution was added. After stirring it for 2 hours, the mixture was put into dry ice and washed and extracted as described in Referencial Example 1 to obtain a crude material. The crude material was washed with a mixed solvent of hexane-ethyl acetate to obtain the title compound.

1. washwashed
2. extractionextracted
3. customto obtain a crude material
4. washThe crude material was washed with a mixed solvent of hexane-ethyl acetate