Hydrochloric Acid → HCID 178479213, compound

HRID 271351Notes

Reaction equation

HRID 271351 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C@H:10]1[CH2:13][C@@H:12]([CH:14]([OH:23])[CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:11]1)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[NH2:7][CH2:8][CH2:9][C@@H:10]1[CH2:11][C@H:12]([CH:14]([OH:23])[CH2:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453496HCID 178453496, compound

Product 1

HCID 178479213HCID 178479213, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 0.8 g of cis-{2-[3-(1-hydroxy-3-phenyl-propyl)-cyclobutyl]-ethyl}-carbamic acid tert-butyl ester and 25 mL of 4N HCl in dioxane was stirred at room temperature for 2 h, then concentrated to dryness and triturated with 50 mL of 5% ether in hexane and the solvents decanted. Drying under vacuum gave 0.8 g of the product as an amber resin: LCMS (m+1)=234.6.

Workup

  1. concentrationconcentrated to dryness
  2. customtriturated with 50 mL of 5% ether in hexane
  3. customthe solvents decanted
  4. customDrying under vacuum

Sources & evidence

ORD record
ord-622a010b73bc4c32b75043e4d5a577a3
Source dataset
uspto-grants-2008_11
Patent number
US07452893B2

Reaction notes

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