Trifluoroacetic acid → HCID 178511508, compound

HRID 271352Notes

Reaction equation

HRID 271352 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH:14]=[CH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10][CH2:9]1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[C:18]1([CH2:17][CH2:16][CH:15]=[CH:14][C@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453879HCID 178453879, compound

Product 1

HCID 178511508HCID 178511508, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.47 g of trans-[4-(4-phenyl-but-1-enyl)-cyclohexyl]-carbamic acid tert-butyl ester in 4 mL of dichloromethane at 0° C. and under nitrogen was added 2 mL of trifluoroacetic acid. The reaction was aged for 1 hour, concentrated under reduced pressure. The resulting oil dissolved in methylene chloride and concentrated to give an oil which was utilized in the next step without purification: LCMS (M+1)=230.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe resulting oil dissolved in methylene chloride
  3. concentrationconcentrated
  4. customto give an oil which
  5. customwas utilized in the next step without purification

Sources & evidence

ORD record
ord-a171f5baefde426fa13f8e96fc6d676b
Source dataset
uspto-grants-2008_11
Patent number
US07452893B2

Reaction notes

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