Hydrazine → HCID 58772846, compound

HRID 271398Notes

Reaction equation

HRID 271398 reaction equation
Cl[C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:5]=[CH:4][N:3]=1.[NH2:21][NH2:22]>C1COCC1>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH:21][NH2:22])[C:7]=2[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 58772837HCID 58772837, compound

Product 1

HCID 58772846HCID 58772846, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a stirred solution of 4-chloro-6-(4-chlorophenyl)-5-phenylpyrimidine (301 mg, 1.0 mmol) in THF (5 mL) at room temperature under argon was added H2NNH2 (160 mg, 5.0 mmol). The reaction mixture was heated at 60° C. under argon for 2 h. Analysis by HPLC/MS indicated that the reaction was complete. The solvent was evaporated and the residue was coevaporated with toluene (2×5 mL) and THF (5 mL), then dried under vacuum. The crude title compound was used directly in the next step. HPLC/MS: retention time=1.89 min, [M+H]30 =297.

Workup

  1. customThe solvent was evaporated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-1b4ee3609f974f3d8ae276aa2c44e4b6
Source dataset
uspto-grants-2008_11
Patent number
US07452892B2

Reaction notes

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