反应详情

温度

100 °C

A suspension of 8-bromo-7-(4-chlorophenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one (48 mg, 0.10 mmol), 4-(hydroxymethyl)phenylboronic acid (46 mg, 0.30 mmol), K3PO4 (63 mg, 0.30 mmol), and Pd(dppf)Cl2.CH2Cl2 (20 mg, 0.025 mmol) in THF (1 mL) at room temperature was degassed by bubbling with argon for 1 min. This was then stirred and heated at 100° C. in a sealed vessel for 3 h. Analysis by HPLC/MS indicated that starting material had been consumed. After the reaction mixture was cooled to room temperature, the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography eluted with ethyl acetate-hexanes. This provided the title compound (6.7 mg) as a light yellow solid. HPLC/MS (methanol-water with 10 mM NH4OAc): retention time=3.53 min, [M+H]30 =512.

1. customby bubbling with argon for 1 min
2. customhad been consumed
3. temperatureAfter the reaction mixture was cooled to room temperature
4. customthe solvent was removed under reduced pressure
5. customThe crude product was purified by silica gel column chromatography
6. washeluted with ethyl acetate-hexanes