Chloride → 7,8-bis(4-chlorophenyl)-5-(4-methylpiperazin-1-yl)-2-(4-(trifluoromethyl)benzyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one
反応式
Cl[C:2]1[N:7]2[C:8](=[O:11])[NH:9][N:10]=[C:6]2[C:5]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:4]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[N:3]=1.[Cl-].[F:27][C:28]([F:38])([F:37])[C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=1.ClC1C=CC(C2N=C([N:52]3[CH2:55][C:54]([NH:59][CH2:60][CH3:61])(C(N)=O)[CH2:53]3)N3C(=O)N(CC)N=C3C=2C2C=CC(Cl)=CC=2)=CC=1>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C:4]2[N:3]=[C:2]([N:59]3[CH2:54][CH2:55][N:52]([CH3:53])[CH2:61][CH2:60]3)[N:7]3[C:8](=[O:11])[N:9]([CH2:33][C:32]4[CH:35]=[CH:36][C:29]([C:28]([F:38])([F:37])[F:27])=[CH:30][CH:31]=4)[N:10]=[C:6]3[C:5]=2[C:12]2[CH:13]=[CH:14][C:15]([Cl:18])=[CH:16][CH:17]=2)=[CH:20][CH:21]=1参加物
5
反応物 4
生成物 1
実験手順
The title compound was prepared in two steps from 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one by nucleophilic displacement of chloride with the requisite amine, followed by alkylation with 4-trifluoromethylbenzyl bromide, in a manner analogous to that in which 1-(7,8-bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide was prepared. HPLC/MS: retention time=3.90 min, [M+H]30 =613.
後処理
- customwas prepared
出典と根拠
- ORDレコード
- ord-e1c6b78532f54d0f80c234b31625066d
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07452892B2
反応ノート
読み込み中…