3-Chloro-5-(chloromethyl)pyridine hydrochloride → 3-[1-(5-Chloro-pyridin-3-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

HRID 271492Notes

Reaction equation

HRID 271492 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1.Cl.[Cl:18][C:19]1[CH:20]=[N:21][CH:22]=[C:23]([CH2:25]Cl)[CH:24]=1>>[Cl:18][C:19]1[CH:24]=[C:23]([CH2:25][N:3]2[CH:4]=[C:5]([C:7]#[C:8][C:9]3[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=3)[C:12]#[N:13])[N:6]=[C:2]2[CH3:1])[CH:22]=[N:21][CH:20]=1

Participants

3

Reactant 2

HCID 672463053-Chloro-5-(chloromethyl)pyridine hydrochlorideHCID 178432699HCID 178432699, compound

Product 1

HCID 114275703-[1-(5-Chloro-pyridin-3-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

Procedure

The title compound, MS: m/e=333.1 (M+H30), was prepared in accordance with the general method of example 1 from 3-(2-methyl-1H-imidazol-4-ylethynyl)-benzonitrile and 3-chloro-5-chloromethyl-pyridine hydrochloride.

Sources & evidence

ORD record
ord-e7ddd7cd61434cff950e16920f28e8ba
Source dataset
uspto-grants-2008_11
Patent number
US07452909B2

Reaction notes

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