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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 271492Generated: October 26, 2026

3-Chloro-5-(chloromethyl)pyridine hydrochloride → 3-[1-(5-Chloro-pyridin-3-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

https://huagongshe.com/reaction/271492

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-5-(chloromethyl)pyridine hydrochlorideHCID 67246305—
ReactantHCID 178432699HCID 178432699—
Product3-[1-(5-Chloro-pyridin-3-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrileHCID 11427570—

Reaction Steps

The title compound, MS: m/e=333.1 (M+H30), was prepared in accordance with the general method of example 1 from 3-(2-methyl-1H-imidazol-4-ylethynyl)-benzonitrile and 3-chloro-5-chloromethyl-pyridine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07452909B2
Source datasetuspto-grants-2008_11
ORD IDord-e7ddd7cd61434cff950e16920f28e8ba
Source noteuspto-grants-2008_11