Hydrochloric Acid → HCID 178517458, compound

Participants

Reaction Steps

2-(Cyclohexylcarbonylamino)benzamide was stirred for 16 h in a mixture of excess 1 M NaOH and EtOH, and the resulting solution was treated with HCl to pH=7 causing the formation of a precipitate. The precipitate was collected by filtration, washed (with water and hexane), and dried under vacuum to give a nearly quantitative yield of 2-cyclohexyl-4-hydroxyquinazoline as a white solid, which was used immediately in the next step.

Provenance & Evidence