Hydrochloric Acid → HCID 178517458, compound

HRID 271541Notes

Reaction equation

HRID 271541 reaction equation
[CH:1]1([C:7]([NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([NH2:14])=[O:13])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].Cl>CCO>[CH:1]1([C:7]2[N:14]=[C:12]([OH:13])[C:11]3[C:10](=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 819654HCID 819654, compound

Product 1

HCID 178517458HCID 178517458, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(Cyclohexylcarbonylamino)benzamide was stirred for 16 h in a mixture of excess 1 M NaOH and EtOH, and the resulting solution was treated with HCl to pH=7 causing the formation of a precipitate. The precipitate was collected by filtration, washed (with water and hexane), and dried under vacuum to give a nearly quantitative yield of 2-cyclohexyl-4-hydroxyquinazoline as a white solid, which was used immediately in the next step.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed (with water and hexane)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-933efebdf0bf4ef5b91b56ef4409fc92
Source dataset
uspto-grants-2008_11
Patent number
US07452912B2

Reaction notes

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