反应详情

To the mixture of 100 mg (0.30 mmoles) of 7-(2,2-Dimethyl-propyl)-6-(4-oxo-piperidin-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile, 40 mg (0.60 mmoles) of [1,2,4]triazol-4-ylamine and 0.16 ml (1.1 mmoles) of triethylamine in 5 ml of CH2Cl2, 58 mg (0.48 mmoles) of MgSO4 is added at ambient temperature and the mixture is stirred for 17.5 hours at ambient temperature. The reaction mixture is filtered to remove MgSO4 and concentrated under reduced pressure to give crude imine. To a solution of crude imine in 5 ml of MeOH, 13 mg (0.33 mmoles) of NaBH4 is added at −10-−20° C., and the reaction mixture is stirred at 0° C. for 1 h. After addition of 5 ml of acetone, the mixture is concentrated, diluted with H2O, and then extracted with CH2Cl2. The combined extrats are washed with brine, dried over MgSO4 and concentrated under reduced pressure. The residue is purified by silica gel column chromatography to give 85 mg of desired 6-(4-amino-piperidin-1-ylmethyl)-7-(2,2-dimethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile in 85% yield.

1. additionis added at ambient temperature
2. filtrationThe reaction mixture is filtered
3. customto remove MgSO4
4. concentrationconcentrated under reduced pressure
5. customto give crude imine
6. stirringthe reaction mixture is stirred at 0° C. for 1 h
7. concentrationthe mixture is concentrated
8. additiondiluted with H2O
9. extractionextracted with CH2Cl2
10. washThe combined extrats are washed with brine
11. dry with materialdried over MgSO4
12. concentrationconcentrated under reduced pressure
13. customThe residue is purified by silica gel column chromatography