HCID 60659962, compound → HCID 62642302, compound

HRID 271668Notes

Reaction equation

HRID 271668 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4]([N+:16]([O-])=O)[CH:3]=1>[Ni].CO>[Br:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]([NH:8][CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 60659962HCID 60659962, compound

Product 1

HCID 62642302HCID 62642302, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

100 mg Raney Nickel are added to a solution of 1.00 g (3.18 mmol) (4-bromo-2-nitro-phenyl)-(2-pyrrolidin-1-yl-ethyl)-amine in 100 mL MeOH. The reaction solution is stirred for 15 min at 3 bar H2 and RT. After filtration the solvent is eliminated i.vac. and the product is further reacted without purification.

Workup

  1. filtrationAfter filtration the solvent
  2. customand the product is further reacted without purification

Sources & evidence

ORD record
ord-3bdfaf628255417c889c3dabee2aa532
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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