Potassium Carbonate → HCID 67363753, compound

HRID 271673Notes

Reaction equation

HRID 271673 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]([NH:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:6][CH:7]=1.[C:17]([O-])([O-])=O.[K+].[K+]>C(O)=O>[Br:1][C:2]1[CH:3]=[C:4]2[N:16]=[CH:17][N:8]([CH2:9][CH2:10][N:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)[C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 62640828HCID 62640828, compound

Product 1

HCID 67363753HCID 67363753, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 470 mg (1.65 mmol) 5-bromo-N2-(2-pyrrolidin-1-yl-ethyl)-pyridine-2,3-diamine in 10 mL formic acid is refluxed for 1.5 h. The mixture is made alkaline with saturated K2CO3 solution and extracted with 40 mL EtOAc. The organic phase is dried over Na2SO4 and the solvent is eliminated i.vac.

Workup

  1. extractionextracted with 40 mL EtOAc
  2. dry with materialThe organic phase is dried over Na2SO4

Sources & evidence

ORD record
ord-a58a51d332404d54a6a649446f3a9fdb
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

Loading…