反应详情

温度

60 °C

0.46 mL (5.4 mmol) C-cyclopropyl-methylamine are added to a solution of 2.03 g (4.5 mmol) 2-{5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-indol-1-yl}-ethyl methanesulphonate in 20 mL DMF and the reaction mixture is stirred for 4 h at 60° C. The mixture is evaporated down i.vac., the residue is stirred with DCM, the precipitate is suction filtered and dried in the air. The product is precipitated as the methanesulphonic acid salt.

1. customThe mixture is evaporated down i.vac
2. stirring, the residue is stirred with DCM
3. filtrationfiltered
4. customdried in the air
5. customThe product is precipitated as the methanesulphonic acid salt