HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl (S)-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-tert-butoxycarbonylaminopropionate → methyl (R)-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-tert-butoxycarbonylaminopropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl (S)-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-tert-butoxycarbonylaminopropionate | HCID 69685372 | — |
| Reactant | methyl (R)-2-tert-butoxycarbonylamino-3-(3'-methylaminomethylbiphenyl-4-yl)propionate | HCID 86601624 | — |
| Product | methyl (R)-3-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-tert-butoxycarbonylaminopropionate | HCID 69686257 | 85% |
Reaction Steps
In a manner similar to the preparation of ethyl (S)-3-{3′-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-tert-butoxycarbonylaminopropionate (Example 28e), using 5.0 g of methyl (R)-2-tert-butoxycarbonylamino-3-(3′-methylaminomethylbiphenyl-4-yl)propionate, 5.6 g of desired amide are obtained with an 85% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452878B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-4693f0628c224077bc51fea081255e58 |
| Source note | uspto-grants-2008_11 |