反应详情

温度

80 °C

23 ml (45.9 mmol) of an aqueous 2M potassium carbonate solution and 1.77 g (1.50 mmol) of tetrakis palladium are introduced into a solution containing 6.64 g (15.3 mmol) of benzyl 3-(4-bromophenyl)-2-tert-butoxycarbonylaminopropionate and 3.45 g (23 mmol) of 3-boronic acid-benzaldehyde (Example 28b) in 75 ml of toluene. The reaction medium is heated at 80° C. for 20 h and, after a return to ambient temperature, extracted with ethyl acetate. The organic phase is washed with a saturated sodium chloride solution, dried over magnesium sulfate and concentrated. The residue obtained is purified by chromatography on a column of silica and eluted with an 8/2 heptane/ethyl acetate mixture. 5.0 g of coupled product are obtained with a 71% yield.

1. extractionafter a return to ambient temperature, extracted with ethyl acetate
2. washThe organic phase is washed with a saturated sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe residue obtained
6. customis purified by chromatography on a column of silica
7. washeluted with an 8/2 heptane/ethyl acetate mixture