反应详情

16.3 g of N-(3',4'-dichlorophenyl)-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole (see Example 3) is put together with 2 drops of triethylamine in 10 ml of glyme (ethylene glycol dimethyl ether), and 3.8 g of methylisocyanate is then added. After 24 hours, the reaction solution is filtered with a filtering auxiliary (Hyflo®) and the filtrate is concentrated by evaporation to leave an oil, which is crystallised in methanol. In this manner is obtained 15 g (76% of theory) of the above product in the form of yellowish crystals, m.p. 141°-142°.

1. additionis then added
2. filtrationthe reaction solution is filtered with a filtering auxiliary (Hyflo®)
3. concentrationthe filtrate is concentrated by evaporation
4. customto leave an oil, which
5. customis crystallised in methanol
6. customIn this manner is obtained 15 g (76% of theory) of the above product in the form of yellowish crystals, m.p. 141°-142°