HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Azido-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol → 1-Amino-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Azido-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol | HCID 59835964 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Amino-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol | HCID 59835981 | — |
Reaction Steps
A solution of 1-azido-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol (1.19, 3.3 mmol) in 30 mL EtOAc was stirred for 2 h under 40 psi of H2 gas in the presence of catalytic 10% Pd/C. After filtration through celite, the reaction mixture was evaporated to give 1-amino-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol in quantitative yield as a clear oil that was used without further purification. ESI-MS 310 (M+H), 332 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452992B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-99a40821f1ac4a24862acd2a8654ca72 |
| Source note | uspto-grants-2008_11 |