反应详情

A solution of 1-azido-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol (1.19, 3.3 mmol) in 30 mL EtOAc was stirred for 2 h under 40 psi of H2 gas in the presence of catalytic 10% Pd/C. After filtration through celite, the reaction mixture was evaporated to give 1-amino-5-{[tert-butyl(dimethyl)silyl]oxy}-3-phenylpentan-3-ol in quantitative yield as a clear oil that was used without further purification. ESI-MS 310 (M+H), 332 (M+Na).

1. filtrationAfter filtration through celite
2. customthe reaction mixture was evaporated