Hydrochloric Acid → HCID 178496781, compound

HRID 272059Notes

Reaction equation

HRID 272059 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[C:18]2[C:13](=[N:14][CH:15]=[C:16]([C:19]3[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=3)[C:22]#[N:23])[CH:17]=2)[N:12](COCC[Si](C)(C)C)[N:11]=1.C[CH2:36][O:37]CC>CO>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[C:18]2[C:13](=[N:14][CH:15]=[C:16]([C:19]3[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=3)[C:22](=[NH:23])[O:37][CH3:36])[CH:17]=2)[NH:12][N:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59836036HCID 59836036, compound

Product 1

HCID 178496781HCID 178496781, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl gas was bubbled through a suspension of 3-[3-(2-Methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-benzonitrile (40 mg, 0.088 mmol) in 2.5 ml of anhydrous MeOH for 3 minutes at 0° C. After stirring for 23 hours at room temperature, ether (10 mL) was added and precipitation occurred. The solid was collected after filtration and dried to afford methyl 3-(3-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl)benzimidate as a yellow solid.

Workup

  1. customprecipitation
  2. customThe solid was collected
  3. filtrationafter filtration
  4. customdried

Sources & evidence

ORD record
ord-d72f95531a1f489bab164eb4a5a9ad69
Source dataset
uspto-grants-2008_11
Patent number
US07452993B2

Reaction notes

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