HRID272077

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6496941

1-(cyclohexylmethyl)piperidin-4-amine

C12H24N2

结构：O=C(O)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID11762778

未命名化合物

PRODUCTS

生成物

结构：O=C(NC1CCN(CC2CCCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID12149968

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by a method similar to Step 5 of Example 1, using 1-cyclohexylmethyl-4-piperidinamine (JP 52122378) and (2R)-1-{(2S)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxylic acid. The compound was obtained as a white solid.

WORKUP

后处理

customThe compound was obtained as a white solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c5f96c50e51f4da08df0afee47231560
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07452908B2
来源说明: uspto-grants-2008_11

反应 SMILES

[CH:1]1([CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:15]1([C:21]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:22][C:23]([N:25]2[CH2:29][CH2:28][CH2:27][C@H:26]2[C:30]([N:32]2[CH2:36][CH2:35][CH2:34][C@@H:33]2[C:37](O)=[O:38])=[O:31])=[O:24])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH:1]1([CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([NH:14][C:37]([C@H:33]3[CH2:34][CH2:35][CH2:36][N:32]3[C:30]([C@@H:26]3[CH2:27][CH2:28][CH2:29][N:25]3[C:23](=[O:24])[CH2:22][C:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)([C:40]3[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=3)[C:46]3[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=3)=[O:31])=[O:38])[CH2:10][CH2:9]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1