HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Cyclohexylmethyl)piperidin-4-amine → (2R)-N-(1-cyclohexylmethyl-4-piperidyl)-1-{(2S)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Cyclohexylmethyl)piperidin-4-amine | HCID 6496941 | — |
| Reactant | (2R)-1-{(2S)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxylic acid | HCID 11762778 | — |
| Product | (2R)-N-(1-cyclohexylmethyl-4-piperidyl)-1-{(2S)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxamide | HCID 12149968 | — |
Reaction Steps
The title compound was prepared by a method similar to Step 5 of Example 1, using 1-cyclohexylmethyl-4-piperidinamine (JP 52122378) and (2R)-1-{(2S)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxylic acid. The compound was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452908B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-c5f96c50e51f4da08df0afee47231560 |
| Source note | uspto-grants-2008_11 |