Iodoethane → HCID 69101657, compound

HRID 272081Notes

Reaction equation

[OH:1][C@H:2]1[C@@H:6]([OH:7])[CH2:5][N:4]([C:8](=[O:29])[CH2:9][C:10]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C@@H:3]1[C:30]([N:32]1[CH2:36][CH2:35][CH2:34][C@@H:33]1[C:37]([NH:39][CH2:40][C@H:41]1[CH2:46][CH2:45][CH2:44][NH:43][CH2:42]1)=[O:38])=[O:31].[CH2:47](I)[CH3:48]>>[CH2:47]([N:43]1[CH2:44][CH2:45][CH2:46][C@H:41]([CH2:40][NH:39][C:37]([C@H:33]2[CH2:34][CH2:35][CH2:36][N:32]2[C:30]([C@@H:3]2[C@@H:2]([OH:1])[C@@H:6]([OH:7])[CH2:5][N:4]2[C:8](=[O:29])[CH2:9][C:10]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:31])=[O:38])[CH2:42]1)[CH3:48]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 12149980HCID 12149980, compound

Product 1

HCID 69101657HCID 69101657, compound

Procedure

The title compound was prepared by a method similar to Example 77, using (2R)-1-{(2S,3R,4S)-3,4-dihydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-((3S)-3-piperidyl-methyl)pyrrolidine-2-carboxamide and ethyl iodide. The compound was obtained as a white solid.

Workup

customThe compound was obtained as a white solid

Sources & evidence

ORD record: ord-94fa9e4bc91247b683245472b4b777ec
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07452908B2

Reaction notes

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