反应详情

A solution of 1.4 g of trans-4-{4-[benzyl((2S)-3-{4-(benzyloxy)-3-[(tert-butoxycarbonyl)(methylsulfonyl)amino]phenoxy)-2-hydroxy-propyl)amino]cyclohexyl}phenyl trifluoromethanesulfonate (1.62 mmol) in a mixture of trifluoroacetic acid (5 ml) and of dichloromethane (45 mol) is stirred for 3 h 20. The solvents are evaporated under reduced pressure and then water, ethyl acetate and an aqueous ammonium solution are added. The organic phase is washed once with water and dried over sodium sulfate. trans-4-{4-[Benzyl((2S)-3-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenoxy}-2-hydroxypropyl)amino]cyclohexyl}phenyl trifluoromethanesulfonate is obtained in the form of an oil (1.27 g, 98%) after evaporation of the solvents under reduced pressure. [M+H+]=763.5.

1. customThe solvents are evaporated under reduced pressure
2. additionwater, ethyl acetate and an aqueous ammonium solution are added
3. washThe organic phase is washed once with water
4. dry with materialdried over sodium sulfate