反应详情

A solution of 4.5 g of ethyl trans-(4-{4-[benzyl(tert-butoxycarbonyl)amino]cyclohexyl}-phenoxy)acetate (9.6 mmol) in a mixture of trifluoroacetic acid (30 ml) and dichloromethane (90 ml) is stirred for 2 h. The solvents are evaporated under reduced pressure and then water, ethyl acetate and a saturated aqueous sodium carbonate solution are added. The organic phase is washed once with water and dried over sodium sulfate. Ethyl trans-{4-[4-(benzylamino)cyclohexyl]phenoxy}acetate is obtained in the form of an oil (3.22 g, 88%) after evaporation of the solvents under reduced pressure. [M+H+]=368.3

1. customThe solvents are evaporated under reduced pressure
2. additionwater, ethyl acetate and a saturated aqueous sodium carbonate solution are added
3. washThe organic phase is washed once with water
4. dry with materialdried over sodium sulfate