HRID272236

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CS(=O)(=O)c1cc(OC[C@@H]2CO2)ccc1OCc1ccccc1

HCID71361016

(2S)-2-{[4-(Benzyloxy)-3-(methanesulfonyl)phenoxy]methyl}oxirane

C17H18O5S

结构：CCOC(=O)c1ccc([C@H]2CC[C@H](NCc3ccccc3)CC2)cc1

HCID178468874

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1ccc([C@H]2CC[C@H](N(Cc3ccccc3)C[C@H](O)COc3ccc(OCc4ccccc4)c(S(C)(=O)=O)c3)CC2)cc1

HCID178468876

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

This product is obtained by carrying out the preparation as described in preparation 3.2 above, using ethyl trans-4-[4-(benzylamino)cyclohexyl]benzoate and 4-benzyloxy-3-methylsulfonyl-1-((2S)-2,3-epoxypropoxy)benzene, disclosed in patent application WO 99/65895, and without adding thereto the solution of hydrochloric acid in ethanol. [M+H+]=672

WORKUP

后处理

customThis product is obtained
customthe preparation
customas described in preparation 3.2 above
additionwithout adding

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c28a944aa16944cbb9938b89de5bd987
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07453010B2
来源说明: uspto-grants-2008_11

反应 SMILES

[CH2:1]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][C@H:42]2[O:44][CH2:43]2)=[CH:36][C:35]=1[S:45]([CH3:48])(=[O:47])=[O:46])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.Cl>C(O)C>[CH2:1]([N:8]([CH2:43][C@H:42]([OH:44])[CH2:41][O:40][C:37]1[CH:38]=[CH:39][C:34]([O:33][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[C:35]([S:45]([CH3:48])(=[O:47])=[O:46])[CH:36]=1)[C@H:9]1[CH2:10][CH2:11][C@H:12]([C:15]2[CH:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:24][CH:25]=2)[CH2:13][CH2:14]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1