反应详情

A suspension of 0.246 g (0.3 mmol) of trans-4-{4-[benzyl((2S)-3-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenoxy}-2-hydroxypropyl)amino]cyclohexyl}-N-[2-(1H-indol-3-yl)ethyl]benzamide and of 0.332 g of palladium-on-charcoal (10% Pd, 50% in water) in a mixture of 5.4 ml of ethanol and 4 ml of tetrahydrofuran is placed under hydrogen atmosphere and is stirred for 3 h. The catalyst is subsequently filtered off and the solvents are evaporated under reduced pressure. The title compound is obtained in the form of a white solid (0.076 g, 40%) after purification on silica gel (eluent: dichloromethane/methanol/aqueous ammonia 99/1/0.1 to 85/15/1.5 gradient in 30 min).

1. filtrationThe catalyst is subsequently filtered off
2. customthe solvents are evaporated under reduced pressure