反应详情

A solution of 0.720 g of ethyl trans-2-{4-[4-({(2S)-3-[4-(benzyloxy)-3-(butylsulfinyl)phenoxy]-2-hydroxypropyl}amino)cyclohexyl]phenoxy}-2,2-dimethylacetate (1.08 mmol) in trifluoroacetic acid (12 ml) is heated at 60° C. for 3 hours. The solvent is evaporated and the residue is treated with a sodium bicarbonate solution and ethyl acetate. The organic phase is separated, dried, filtered and evaporated under vacuum. The product thus obtained is purified by flash chromatography, elution being carried out with a methylene chloride/methanol/aqueous ammonia (9/1/0.1) mixture. The title product is obtained in the form of a solid (0.31 g, 50%).

1. customThe solvent is evaporated
2. additionthe residue is treated with a sodium bicarbonate solution and ethyl acetate
3. customThe organic phase is separated
4. customdried
5. filtrationfiltered
6. customevaporated under vacuum
7. customThe product thus obtained
8. customis purified by flash chromatography, elution