反应详情

The compound of Example 287 was reduced in the same manner as in Reference Example 123 and the resulting compound (107 mg) was dissolved in tetrahydrofuran (5.0 mL). A 1 mol/L TBAF-tetrahydrofuran solution (160 μL) was added dropwise and the mixture was stirred for 3 hours at room temperature. Subsequently, water was added and the reaction mixture was extracted with ethyl acetate. The extract was washed sequentially with water and a saturated aqueous solution of sodium chloride and the organic phase was dried over anhydrous sodium sulfate. The solvent was removed by distillation and the residue was purified on a silica gel column chromatography (ethyl acetate only) to obtain the desired product as a colorless oil (47 mg).

1. extractionthe reaction mixture was extracted with ethyl acetate
2. washThe extract was washed sequentially with water
3. dry with materiala saturated aqueous solution of sodium chloride and the organic phase was dried over anhydrous sodium sulfate
4. customThe solvent was removed by distillation
5. customthe residue was purified on a silica gel column chromatography (ethyl acetate only)