4-Fluorobenzoyl chloride → 4-Fluoro-N-(2,4,6,7-tetramethyl-3-phenyl-5-benzofuranyl)benzamide

HRID 272393Notes

Reaction equation

HRID 272393 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:16]([CH3:17])=[C:15]([CH3:18])[C:14]([NH2:19])=[C:13]([CH3:20])[C:5]=2[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>C(OCC)(=O)C.CCCCCC>[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH:19][C:14]2[C:15]([CH3:18])=[C:16]([CH3:17])[C:4]3[O:3][C:2]([CH3:1])=[C:6]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[C:5]=3[C:13]=2[CH3:20])=[O:27])=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 68886540HCID 68886540, compound

Product 1

HCID 102935794-Fluoro-N-(2,4,6,7-tetramethyl-3-phenyl-5-benzofuranyl)benzamideYield 80%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By using 2,4,6,7-tetramethyl-3-phenyl-1-benzofuran-5-amine and 4-fluorobenzoyl chloride, the title compound was synthesized according to Example 1b. Yield: 80%. Melting point: 242-245° C. (Ethyl acetate-hexane).

Sources & evidence

ORD record
ord-0acc338a7cca4e4da9d2a44de9ab7e5c
Source dataset
uspto-grants-2008_11
Patent number
US07456162B2

Reaction notes

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