Piperazine, 1-cyclopentyl-4-(4-nitro-2-pyridinyl)- → HCID 62367922, compound

HRID 272529Notes

Reaction equation

HRID 272529 reaction equation
[CH:1]1([N:6]2[CH2:11][CH2:10][N:9]([C:12]3[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][N:13]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[CH:1]1([N:6]2[CH2:7][CH2:8][N:9]([C:12]3[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][N:13]=3)[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 2

HCID 51105608Piperazine, 1-cyclopentyl-4-(4-nitro-2-pyridinyl)-HCID 178418361HCID 178418361, compound

Product 1

HCID 62367922HCID 62367922, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 2.85 g (10 mmol) 1-cyclopentyl-4-(4-nitro-pyridin-2-yl)-piperazine and 0.285 g Pd/C (10%) in 25 ml methanol was treated with 1 bar hydrogen at room temperature for 3 h. After filtration the mixture was evaporated to dryness to yield 2.34 g (92%) of the title compound as brownish solid. (m/e): 247.4 (MH+; 100%).

Workup

  1. filtrationAfter filtration the mixture
  2. customwas evaporated to dryness

Sources & evidence

ORD record
ord-c6a40dfee73b4fb88f7cd0ea0f65896c
Source dataset
uspto-grants-2008_11
Patent number
US07456175B2

Reaction notes

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